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Functional Implications of Interleukin-1β Based on the Three-dimensional Structure by Dr. B. Veerapandian; Gary L. Gilliland; Reetta Raag; Anders L. Svensson; Yoshihiro Masui; Yoshikatsu Hirai; Dr. Thomas L. Poulos is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Functional Implications of Interleukin-1β Based on the Three-dimensional Structure about?
## Abstract The molecular structure of interleukin‐1β, a hormone‐like cytokine with roles in several disease processes, has been determined at 2.0 Å resolution and refined to a crystallographic __R__‐factor of 0.19. The frame‐work of this molecule consists of 12 antiparallel β‐strands exhibiting pseudo‐3‐fold symmetry. Six of the strands make up a β‐barrel with polar residues concentrated at either end. Analysis of the three‐dimensional structure, together with results from site‐directed mutagenesis and biochemical and immunological studies, suggest that the core of the β‐barrel plays an important functional role. A large patch of charged residues on one end of the barrel is proposed as the binding surface with which IL‐1 interacts with its receptor.
Who reads Functional Implications of Interleukin-1β Based on the Three-dimensional Structure?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Dr. B. Veerapandian; Gary L. Gilliland; Reetta Raag; Anders L. Svensson; Yoshihiro Masui; Yoshikatsu Hirai; Dr. Thomas L. Poulos
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0887-3585)
- Published
- 1992
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)