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Signaling Pathways Governing Glioma Cancer Stem Cells Behavior by Ava Nasrolahi; Shirin Azizidoost; Klaudia Radoszkiewicz; Sajad Najafi; Farhoodeh Ghaedrahmati; Omid Anbiyaee; Seyed Esmaeil Khoshnam; Maryam Farzaneh; Shahab Uddin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Signaling Pathways Governing Glioma Cancer Stem Cells Behavior about?

Glioma is the most common malignant brain tumor that develops in the glial tissue. Several studies have identified that glioma cancer stem cells (GCSCs) play important roles in tumor-initiating features in malignant gliomas. GCSCs are a small population in the brain that presents an essential role in the metastasis of glioma cells to other organs. These cells can self-renew and differentiate, which are thought to be involved in the pathogenesis of glioma. Therefore, targeting GCSCs might be a novel strategy for the treatment of glioma. Accumulating evidence revealed that several signaling pathways, including Notch, TGF-β, Wnt, STAT3, AKT, and EGFR mediated GCSC growth, proliferation, migration, and invasion. Besides, non-coding RNAs (ncRNAs), including miRNAs, circular RNAs, and long ncRNAs have been found to play pivotal roles in the regulation of GCSC pathogenesis and drug resistance. Therefore, targeting these pathways could open a new avenue for glioma management. In this review, we summarized critical signaling pathways involved in the stimulation or prevention of GCSCs tumorigenesis and invasiveness.

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Author

Ava Nasrolahi; Shirin Azizidoost; Klaudia Radoszkiewicz; Sajad Najafi; Farhoodeh Ghaedrahmati; Omid Anbiyaee; Seyed Esmaeil Khoshnam; Maryam Farzaneh; Shahab Uddin

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)