About this document
Antineoplastic Agents Overview by Muhamed Arsalan is a document available to read on EtoBox.
1) Alkylating agents are a class of drugs that form covalent bonds with DNA and other biomolecules, leading to cell death through DNA disruption and apoptosis. Resistance can occur via decreased drug uptake, increased detoxification, enhanced DNA repair, or lack of drug activation. 2) Nitrogen mustards like mechlorethamine are dialkylating agents that form reactive aziridinium cations, alkylating two sites in DNA. Their reactivity led to less reactive derivatives like chlorambucil and melphalan. 3) Anti
- Author
- Muhamed Arsalan
- Language
- EN