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Relationships Among Liver and Kidney Volumes, Lean Body Mass and Drug Clearance by Sumith Nawaratne; Jo-anne E. Brien; Ego Seeman; Robert Fabiny; John Zalcberg; Walter Cosolo; Peter Angus; Denis J. Morgan is a Medicine article available to read on EtoBox.
What is Relationships Among Liver and Kidney Volumes, Lean Body Mass and Drug Clearance about?
__Aims__ To determine whether lean body mass (LBM), a possible surrogate of liver and kidney volumes, correlates with hepatic and renal drug clearances. __Methods__ Twenty‐one disease‐free patients with a history of cancer and with normal hepatic and renal function were studied. Salivary pharmacokinetics of oral antipyrine (1200 mg) and 24 h creatinine clearance were determined following the determination of LBM by dual energy X‐ray absorptiometry and the determination of liver and kidney volumes by helical CT scanning. __Results Liver volume correlated with LBM (r^2^=0.21, P=0.04), body surface area (BSA) (r^2^=0.54, P<0.001), and total body weight (TBW) (r^2^=0.61, P<0.001). Kidney volume correlated with LBM (r^2^=0.49, P<0.001), BSA (r^2^=0.43, P=0.002) and TBW (r^2^=0.24, P__=0.03). Stepwise multiple regression analysis, incorporating the independent variables of age, height, weight, sex, BSA, LBM, alcohol consumption, smoking status and liver volume and the dependent variable antipyrine clearance, indicated that LBM was the only independent correlate of antipyrine clearance. A stepwise multiple regression analysis with kidney volume in the independent variables, and creatinine
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- Author
- Sumith Nawaratne; Jo-anne E. Brien; Ego Seeman; Robert Fabiny; John Zalcberg; Walter Cosolo; Peter Angus; Denis J. Morgan
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)
- Published
- 1998
- Language
- EN
- Field
- Medicine (Health Sciences)