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Can I read Comparative Effects of Raloxifene and Alendronate on Fracture Outcomes in Postmenopausal Women with Low Bone Mass on EtoBox?
Comparative Effects of Raloxifene and Alendronate on Fracture Outcomes in Postmenopausal Women with Low Bone Mass by Robert R. Recker; David Kendler; Christopher P. Recknor; Theodore W. Rooney; E. Michael Lewiecki; Wulf H. Utian; Jane A. Cauley; Joanne Lorraine; Yongming Qu; Pandurang M. Kulkarni; Carol L. Gaich; Mayme Wong; Leo Plouffe Jr.; John L. Stock is a Medicine article available to read on EtoBox.
What is Comparative Effects of Raloxifene and Alendronate on Fracture Outcomes in Postmenopausal Women with Low Bone Mass about?
The double-blind, randomized raloxifene alendronate comparison trial was the first study designed to compare two osteoporosis therapies head-to-head for fracture risk reduction. The original protocol planned to treat 3000 postmenopausal women with alendronate 10 mg/day (ALN) or raloxifene 60 mg/day (RLX) for 5 years, and to recruit women (50-80 years old) with a femoral neck bone mineral density (BMD) T-score between -2.5 and -4.0, inclusive, no prevalent vertebral fractures, and no prior bone-active agent use. The trial was stopped early, due to difficulty in finding treatment-naïve women to meet enrollment goals within the planned timeline, resulting in insufficient power to show non-inferiority between therapies in the primary endpoint (number of women with >or=1 new osteoporotic vertebral or nonvertebral fracture). Except for vertebral fractures, fracture analyses were based upon 1412 of the 1423 women randomized (mean age of 66 years). After 312+/-254 days (mean+/-SD), 22 women in the ALN group and 20 in the RLX group had new vertebral or nonvertebral fractures. Four women in the ALN group and none in the RLX group had moderate/severe vertebral fractures, a pre-specified endpo
Who reads Comparative Effects of Raloxifene and Alendronate on Fracture Outcomes in Postmenopausal Women with Low Bone Mass?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Robert R. Recker; David Kendler; Christopher P. Recknor; Theodore W. Rooney; E. Michael Lewiecki; Wulf H. Utian; Jane A. Cauley; Joanne Lorraine; Yongming Qu; Pandurang M. Kulkarni; Carol L. Gaich; Mayme Wong; Leo Plouffe Jr.; John L. Stock
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 8756-3282)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)