Can I read Enantioselective Hydroalkylation of α,β-Unsaturated Amides through Reversed syn-Hydrometallation of NiH on EtoBox?

Enantioselective Hydroalkylation of α,β-Unsaturated Amides through Reversed syn-Hydrometallation of NiH by Fang Zhou; Shaolin Zhu is a scholarly article available to read on EtoBox.

What is Enantioselective Hydroalkylation of α,β-Unsaturated Amides through Reversed syn-Hydrometallation of NiH about?

Enantioselective synthesis of a wide range of structurally diverse β-chiral amides has been achieved through nickel-catalyzed regio-reversed hydroalkylation of α,β-unsaturated amides with alkyl iodides in the presence of a hydrosilane. Different from the classical homolysis/enantioconvergent recombination process of Ni(III) intermediates as the enantio-determining step, chiral induction in this reductive hydroalkylation was achieved through an enantiodifferentiating regio-reversed __syn__-hydrometallation process of α,β-unsaturated amides.

Author

Fang Zhou; Shaolin Zhu

Publisher

American Chemical Society (ACS)

Published

2021

Language

EN