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Use of cyclin D1 in conjunction with human papillomavirus status to predict outcome in oropharyngeal cancer by Angela M. Hong; Timothy A. Dobbins; Cheok S. Lee; Deanna Jones; Jimin Fei; Jonathan R. Clark; Bruce K. Armstrong; Gerald B. Harnett; Christopher G. Milross; Nham Tran; Luiza D. Peculis; Cecilia Ng; Andrew G. Milne; Christine Loo; Louise J. Hughes; Dion F. Forstner; Christopher J. O'Brien; Barbara R. Rose is a Medicine article available to read on EtoBox.

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## Abstract There is increasing use of multiple molecular markers to predict prognosis in human cancer. Our aim was to examine the prognostic significance of cyclin D1 and retinoblastoma (pRb) expression in association with human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma. Clinical records and specimens of 226 patients with follow‐up from 1 to 235 months postdiagnosis were retrieved. Tumor HPV status was determined by HPV E6‐targeted multiplex real‐time PCR/p16 semiquantitative immunohistochemistry and cyclin D1 and pRb expression by semiquantitative immunohistochemistry. Determinants of recurrence and mortality hazards were modeled using Cox regression with censoring at dates of last follow‐up. The HPV‐positivity rate was 37% (91% type 16). HPV was a predictor of recurrence, an event (recurrence or death) and death after adjustment for clinicopathological variables. There were inverse relationships between HPV status and cyclin D1 and pRb. On univariate analysis, cyclin D1 predicted locoregional recurrence, event and death and pRb predicted event and death. Within the HPV‐positive group, after adjusting for clinicopathological factors, patients with cycli

Who reads Use of cyclin D1 in conjunction with human papillomavirus status to predict outcome in oropharyngeal cancer?

Author

Angela M. Hong; Timothy A. Dobbins; Cheok S. Lee; Deanna Jones; Jimin Fei; Jonathan R. Clark; Bruce K. Armstrong; Gerald B. Harnett; Christopher G. Milross; Nham Tran; Luiza D. Peculis; Cecilia Ng; Andrew G. Milne; Christine Loo; Louise J. Hughes; Dion F. Forstner; Christopher J. O'Brien; Barbara R. Rose

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2011

Language

EN

Field

Medicine (Health Sciences)