Opening book details…
Can I read High Expression of Oxidative Phosphorylation Genes Predicts Improved Survival in Squamous Cell Carcinomas of the Head and Neck and Lung on EtoBox?
High Expression of Oxidative Phosphorylation Genes Predicts Improved Survival in Squamous Cell Carcinomas of the Head and Neck and Lung by Frederick, Mitchell; Skinner, Heath D.; Kazi, Sawad A.; Sikora, Andrew G.; Sandulache, Vlad C. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is High Expression of Oxidative Phosphorylation Genes Predicts Improved Survival in Squamous Cell Carcinomas of the Head and Neck and Lung about?
Mitochondrial activity is a critical component of tumor metabolism, with profound implications for tumorigenesis and treatment response. We analyzed clinical, genomic and expression data from patients with oral cavity squamous cell carcinoma (OCSCC) in order to map metabologenomic events which may correlate with clinical outcomes and identified nuclear genes involved in oxidative phosphorylation and glycolysis (OXPHOG) as a critical predictor of patient survival. This correlation was validated in a secondary unrelated set of lung squamous cell carcinoma (LUSC) and was shown to be driven largely by over-expression of nuclear encoded components of the mitochondrial electron transport chain (ETC) coordinated with an increase in tumor mitochondrial DNA copy number and a strong threshold effect on patient survival. OCSCC and LUSC patients with a favorable OXPHOG signature demonstrated a dramatic (>2fold) improvement in survival compared to their counterparts. Differential OXPHOG expression correlated with varying tumor immune infiltrates suggesting that the interaction between tumor metabolic activity and tumor associated immunocytes may be a critical driver of improved clinical outcome
Who reads High Expression of Oxidative Phosphorylation Genes Predicts Improved Survival in Squamous Cell Carcinomas of the Head and Neck and Lung?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Frederick, Mitchell; Skinner, Heath D.; Kazi, Sawad A.; Sikora, Andrew G.; Sandulache, Vlad C.
- Publisher
- Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)