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Improved Biocompatibility of Hydroxyapatite Thin Film Prepared by Aerosol Deposition by Dong‐Soo Park; In‐Sook Kim; Hyeongil Kim; Alex Hung Kuo Chou; Byung‐Dong Hahn; Long‐Hao Li; Soon‐Jung Hwang is a Medicine article available to read on EtoBox.

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## Abstract Technical development for an efficient coating of bioactive materials improves the characteristics of a fully functional implant. The aim of this study was to investigate the osteoinductive effect of a newly developed hydroxyapatite (HA)‐coating technique using aerosol deposition without post‐heat treatment [room temperature (RT) group] on the titanium (Ti) dental implant __in vitro__ and __in vivo__, compared with that of HA coating with post‐heat treatment (HT‐400 group) or machined surface (control group). Cell proliferation or attachment on the HA‐coated Ti surface was assessed using tetrazolium salt, WST‐8 or scanning electron microscopy (SEM). Human osteoblasts (HOB) on RT group were well attached and grew alike in the control or HT‐400 group. The alkaline phosphatase activity of HOB cultured on RT and HT‐400 group was significantly higher than the control group (__p__ < 0.05). Evaluation by SEM, TEM, and XRD demonstrated that aerosol deposition facilitated HA particles to form a dense and uniform HA layer in the RT group despite no post‐heating. In a rabbit tibia model (__n__ = 3), the ratios of bone implant contact and bone area in the RT group (49.88%, 86.05%)

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Author

Dong‐Soo Park; In‐Sook Kim; Hyeongil Kim; Alex Hung Kuo Chou; Byung‐Dong Hahn; Long‐Hao Li; Soon‐Jung Hwang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1552-4973)

Published

2010

Language

EN

Field

Medicine (Health Sciences)