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Single-stranded DNA binding proteins : methods and protocols by Aimee H. Marceau (auth.), James L. Keck (eds.) is a nonfiction available to read on EtoBox.

What is Single-stranded DNA binding proteins : methods and protocols about?

The genomes of cellular organisms are organized as double-stranded DNA, a structure that must be unwound to provide DNA replication, recombination, and repair machinery access to genomic information. However, DNA unwinding comes with inherent risks to genome stability. To help mediate these risks, bacterial, archael, and eukaryotic cells have evolved protective ssDNA-binding proteins (SSBs) that bind ssDNA with high affinity and specificity. SSBs also aid genome metabolic processes through direct interactions with key proteins in genome maintenance enzymes. Single-Stranded DNA Binding Proteins: Methods and Protocols assembles methods developed for examining the fundamental properties of SSBs and for exploiting the biochemical functions of SSBs for their use as in vitro and in vivo reagents. Clearly and concisely organized, the volume opens with an introduction to the structures and functions of SSBs, followed protocols for studying SSB/DNA complexes, methods for studying SSB/heterologous protein complexes, protocols for interrogating post-translational modifications of SSBs, and concludes with uses of fluorescently-labeled SSBs for in vitro and in vivo studies of genome mainten

Who reads Single-stranded DNA binding proteins : methods and protocols?

Author

Aimee H. Marceau (auth.), James L. Keck (eds.)

Publisher

Humana Press : Imprint : Humana Press

Published

2012

Language

EN

ISBN

9781627030311

Category

nonfiction

Subjects

Science, Chemistry, Stem