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Association of Small Vessel Disease with Tau Pathology by Alifiya Kapasi; L. Yu; V. Petyuk; K. Arfanakis; D. A. Bennett; J. A. Schneider is a Medicine article available to read on EtoBox.

What is Association of Small Vessel Disease with Tau Pathology about?

## Abstract Emerging evidence suggests that small vessel disease (SVD) is a risk factor for clinical dementia and may contribute to AD neuropathological changes. Watershed brain regions are located at the most distal areas between arterial territories, making them vulnerable to SVD-related changes. We examined the association of pathologic markers of SVD, specifically arteriolosclerosis in watershed brain regions, with AD pathologic changes. Participants (N = 982; mean age-at-death = 90; 69% women) were enrolled as part of one of two cohort studies of aging and dementia. At autopsy, neuropathological evaluation included semi-quantitative grading of arteriolosclerosis pathology from 2 cortical watershed regions: the anterior watershed (AWS) and posterior watershed (PWS), densities for cortical β-amyloid and tau-tangle pathology, and other common age-related pathologies. Linear regression models examined the association of watershed arteriolosclerosis pathology with β-amyloid and tau-tangle burden. In follow-up analyses, available ex-vivo MRI and proteomics data in a subset of decedents were leveraged to examine the association of whole brain measure of WMH, as a presumed MRI marker

Who reads Association of Small Vessel Disease with Tau Pathology?

Author

Alifiya Kapasi; L. Yu; V. Petyuk; K. Arfanakis; D. A. Bennett; J. A. Schneider

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Life Sciences)