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The PARACELSUS score: a novel diagnostic tool for pyoderma gangrenosum by F. Jockenhöfer; U. Wollina; K.A. Salva; S. Benson; J. Dissemond is a Medicine article available to read on EtoBox.

What is The PARACELSUS score: a novel diagnostic tool for pyoderma gangrenosum about?

## Background: The lack of objective diagnostic criteria renders pyoderma gangrenosum (PG) a diagnosis of exclusion. The diagnostic approaches proposed to date have not been systematically evaluated. Thus, PG remains a challenging and frequently misdiagnosed disorder. ## Objectives: To develop and assess a comprehensive yet clinically practicable as well as sensitive diagnostic scoring system for PG. Methods: Clinical history and images of a total of 60 subjects with previously confirmed PG located on the lower extremity as well as a control cohort of 50 patients with venous leg ulcers were retrospectively evaluated by expert teams at two tertiary dermatological centres specializing in wound care using a newly developed diagnostic scoring system composed of ten criteria. ## Results: The three major diagnostic criteria are rapidly progressing disease, assessment (absence) of relevant differential diagnoses and reddish-violaceous wound border (prevalent in 98.3% of PG patients, respectively). Minor criteria (evident in 61-95% of PG cases) include amelioration (alleviation) by immunosuppressant drugs, characteristically irregular shape of ulceration, extreme pain >4/10 on visual analo

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Author

F. Jockenhöfer; U. Wollina; K.A. Salva; S. Benson; J. Dissemond

Publisher

Oxford University Press (OUP)

Published

2018

Language

EN

Field

Medicine (Health Sciences)