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Toxicokinetic assessment of methylphenidate (Ritalin^®^) in a 13‐week oral toxicity study in dogs by Ray Bakhtiar; Luis Ramos; Francis L. S. Tse is a Chemistry article available to read on EtoBox.

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## Abstract Ritalin^®^ or methylphenidate (MPH) is often prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. The therapeutic activity of MPH is principally due to d‐__threo__‐[2__R__,2′__R__]‐MPH. Hence, in order to establish a kinetic relationship between doses and exposure levels in a non‐rodent species, a 13‐week oral (capsule) toxicity study of d‐__threo__‐[2__R__,2′__R__]‐MPH was performed in beagle dogs. A previously reported chiral liquid chromatography tandem mass spectrometry (LC‐MS/MS) with a limit of quantification (LLOQ) of 1.09 ng/ml was utilized. The results of this study indicated that MPH appeared to be rapidly absorbed in dogs following oral administration. The peak concentration was reached within 1–2 h. Based on the area under the curve (AUC) values, the plasma exposure of d‐MPH was over‐proportional to the dose. With the exception of two groups of animals (male/female, 7.5 mg/kg/day on day 1 and male/female, 3.0 mg/kg/day on week 7), the data showed no difference in MPH concentrations between the male and female dogs. Taking the statistical variations into account, concentrations of d‐MPH that were observed after 7.5 m

Who reads Toxicokinetic assessment of methylphenidate (Ritalin^®^) in a 13‐week oral toxicity study in dogs?

Author

Ray Bakhtiar; Luis Ramos; Francis L. S. Tse

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0269-3879)

Published

2003

Language

EN

Field

Chemistry (Physical Sciences)