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Platelet and Endothelial Adhesion on Fluorosurfactant Polymers Designed for Vascular Graft Modification by Chad Tang; Faina Kligman; Coby C. Larsen; Kandice Kottke-Marchant; Roger E. Marchant is a Engineering article available to read on EtoBox.

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## Abstract A prominent failure mechanism of small diameter expanded polytetrafluoroethylene (ePTFE) vascular grafts is platelet‐mediated thrombosis. We have designed a surface modification for ePTFE consisting of a self‐assembling fluorosurfactant polymer (FSP) bearing biologically active ligands, including adhesive peptides and polysaccharide moieties. The goal of this biomimetic construct is to improve graft hemocompatibility by promoting rapid surface endothelialization, whereas minimizing platelet adhesion. Here we present a direct comparison of platelet and endothelial cell (EC) adhesion to FSPs containing one of three cell‐adhesion peptides: cyclic Arg‐Gly‐Asp‐D‐Phe‐Glu (cRGD), cyclic \*Cys‐Arg‐Arg‐Glu‐Thr‐Ala‐Trp‐Ala‐Cys\* (cRRE, \*denotes disulfide bond cyclization), linear Gly‐Arg‐Gly‐Asp‐Ser‐Pro‐Ala (RGD), or a polysaccharide moiety: oligomaltose (M‐7), later designed to prevent nonspecific protein adhesion. Measurements of soluble peptide‐integrin binding indicated that cRRE exhibits very low affinity for the α~IIb~β~3~ platelet fibrinogen receptor. Static and dynamic adhesion of washed, activated platelets on FSP‐modified surfaces revealed that M‐7 and cRRE promote sig

Who reads Platelet and Endothelial Adhesion on Fluorosurfactant Polymers Designed for Vascular Graft Modification?

Author

Chad Tang; Faina Kligman; Coby C. Larsen; Kandice Kottke-Marchant; Roger E. Marchant

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2008

Language

EN

Field

Engineering (Physical Sciences)