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Unveiling the Veil of Lactate in Tumor-associated Macrophages: a Successful Strategy for Immunometabolic Therapy by Hongxia Tao; Xuansheng Zhong; Anqi Zeng; Linjiang Song is a Immunology and Microbiology article available to read on EtoBox.

What is Unveiling the Veil of Lactate in Tumor-associated Macrophages: a Successful Strategy for Immunometabolic Therapy about?

Lactate, traditionally regarded as a metabolic waste product at the terminal of the glycolysis process, has recently been found to have multifaceted functional roles in metabolism and beyond. A metabolic reprogramming phenomenon commonly seen in tumor cells, known as the “Warburg effect,” sees high levels of aerobic glycolysis result in an excessive production of lactate. This lactate serves as a substrate that sustains not only the survival of cancer cells but also immune cells. However, it also inhibits the function of tumor-associated macrophages (TAMs), a group of innate immune cells ubiquitously present in solid tumors, thereby facilitating the immune evasion of malignant tumor cells. Characterized by their high plasticity, TAMs are generally divided into the pro-inflammatory M1 phenotype and the pro-tumour M2 phenotype. Through a process of ‘education’ by lactate, TAMs tend to adopt an immunosuppressive phenotype and collaborate with tumor cells to promote angiogenesis. Additionally, there is growing evidence linking metabolic reprogramming with epigenetic modifications, suggesting the participation of histone modification in diverse cellular events within the tumor microenvi

Who reads Unveiling the Veil of Lactate in Tumor-associated Macrophages: a Successful Strategy for Immunometabolic Therapy?

Author

Hongxia Tao; Xuansheng Zhong; Anqi Zeng; Linjiang Song

Publisher

Frontiers Media SA

Published

2023

Language

EN

Field

Immunology and Microbiology (Life Sciences)