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Development of cryostage for matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry by Yasuhide Naito; Keiko Miyabayashi; Kazuo Tsujimoto is a Chemistry article available to read on EtoBox.

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Matrix-assisted laser desorption/ionization (MALDI) is generally carried out at ambient temperature. Lowering the temperature of a MALDI target is vitally important to IR-MALDI and the image analysis of biological tissues, and is expected to improve the interface between MALDI and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) by reducing a large kinetic energy distribution of MALDI-generated ions. A new MALDI source equipped with a cryostage capability has been developed for attaching to a commercial FT-ICR instrument. The lowest target temperature of -20 • C was achieved by the cryostage based on a Peltier device. MALDI-generated ions can be focused and be confined by an originally designed quadrupole ion guide which is pressurized with a collisional buffer gas introduced via a pulsed valve. The effect of lowered target temperature on gaining mass spectrometric peak magnitudes was examined. It was found that the observed average molecular weight of MALDI-generated polyethylene glycol 600 (PEG 600) ions was increased upon decreasing the target temperature. Cryo-MALDI has become a feasible technique and may boost the performance and versatility of MALDI FT-

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Author

Yasuhide Naito; Keiko Miyabayashi; Kazuo Tsujimoto

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1387-3806)

Published

2002

Language

EN

Field

Chemistry (Physical Sciences)