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Innate and Innate-Like Cells: The Future of Chimeric Antigen Receptor (CAR) Cell Therapy by Cortés-Selva, Diana; Dasgupta, Bidisha; Singh, Sanjaya; Grewal, Iqbal S. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Innate and Innate-Like Cells: The Future of Chimeric Antigen Receptor (CAR) Cell Therapy about?

Conventional αβ CAR-T cell-based approaches have revolutionized the field of cancer immunotherapy, but hurdles remain, especially for solid tumors. Novel strategies in conjunction with alternative cell types are therefore required for effective CAR-based therapies. In this respect, innate and innate-like cells with unique immune properties, such as natural killer (NK) cells, NKT cells, γδ T cells, and macrophages, are promising alternatives to αβ CAR-T adoptive therapy. We review the applicability of these cells in the context of CAR therapy, focusing on therapies under development, the advantages of these approaches relative to conventional CAR-T cells, and their potential in allogeneic therapies. We also discuss the inherent limitations of these cell types and approaches, and outline numerous strategies to overcome the associated obstacles.

Who reads Innate and Innate-Like Cells: The Future of Chimeric Antigen Receptor (CAR) Cell Therapy?

Author

Cortés-Selva, Diana; Dasgupta, Bidisha; Singh, Sanjaya; Grewal, Iqbal S.

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-6147)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)