About this Medicine article

Assessment of Noninvasive Markers of Steatosis and Liver Fibrosis in Human Immunodeficiency Virus-Monoinfected Patients on Stable Antiretroviral Regimens by C Busca; M Sánchez-Conde; M Rico; M Rosas; E Valencia; A Moreno; V Moreno; L Martín-Carbonero; S Moreno; I Pérez-Valero; J I Bernardino; J R Arribas; J González; A Olveira; P Castillo; M Abadía; L Guerra; C Mendez; M L Montes is a Medicine article available to read on EtoBox.

## Abstract ## Background Nonalcoholic fatty liver disease (NAFLD) is a major nonacquired immune deficiency syndrome-defining condition for persons with human immunodeficiency virus (PWH). We aimed to validate noninvasive tests for the diagnosis of NAFLD in PWH. ## Methods This is a cross-sectional study of PWH on stable antiretroviral therapy with persistently elevated transaminases and no known liver disease. The area under the receiver operating characteristic curve (AUROC) was calculated to compare the diagnostic accuracy of liver biopsy with abdominal ultrasound, transient elastography (TE) (including controlled attenuation parameter [CAP]), and noninvasive markers of steatosis (triglyceride and glucose index [TyG], hepatic steatosis index [HSI], fatty liver index [FLI]) and fibrosis ([FIB]-4, aminotransferase-to-platelet ratio index [APRI], NAFLD fibrosis score). We developed a diagnostic algorithm with serial combinations of markers. ## Results Of 146 patients with increased transaminase levels, 69 underwent liver biopsy (90% steatosis, 61% steatohepatitis, and 4% F ≥3). The AUROC for steatosis was as follows: ultrasound, 0.90 (0.75–1); CAP, 0.94 (0.88–1); FLI, 0.81 (0.58–1)

Author

C Busca; M Sánchez-Conde; M Rico; M Rosas; E Valencia; A Moreno; V Moreno; L Martín-Carbonero; S Moreno; I Pérez-Valero; J I Bernardino; J R Arribas; J González; A Olveira; P Castillo; M Abadía; L Guerra; C Mendez; M L Montes

Publisher

Oxford University Press (OUP)

Published

2022

Language

EN

Field

Medicine (Health Sciences)