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Urinary Aflatoxin Levels, Hepatitis-b Virus Infection and Hepatocellular Carcinoma in Taiwan by Maureen C. Hatch; Chien-Jen Chen; Bruce Levin; Bu-Tian Ji; Guang-Yang Yang; Shang-Wei Hsu; Lian-Wen Wang; Ling-Ling Hsieh; Regina M. Santella is a Medicine article available to read on EtoBox.
What is Urinary Aflatoxin Levels, Hepatitis-b Virus Infection and Hepatocellular Carcinoma in Taiwan about?
Using a urinary immunoassay to measure aflatoxin metabolites, we examined the associations between exposure to aflatoxin, chronic infection with the hepatitis-B virus (HBV) and background rates of hepatocellular carcinoma (HCC) mortality in a cross-sectional survey of 250 residents from 8 areas of Taiwan with a 4-fold variation in age-adjusted HCC mortality. Specimens of fasting blood and overnight urines were used to determine HBV carrier status and excretion of aflatoxin in the subjects surveyed. While the prevalence of hepatitis-B virus carriers showed moderate variability, there was a 500-fold range in urinary aflatoxin levels. Mean log-transformed levels of aflatoxin metabolites were similar in males and females and in HBV carriers and non-carriers. In the 8 townships, HCC mortality correlated positively with both area HBV carrier prevalence and mean aflatoxin levels. The primary analyses, however, were conducted at the individual level. Each subject's aflatoxin level was treated as the response variable in a multiple regression model, and the corresponding sex-specific area HCC rate was included as a predictor along with the individual's carrier status, age and sex; alcohol c
Who reads Urinary Aflatoxin Levels, Hepatitis-b Virus Infection and Hepatocellular Carcinoma in Taiwan?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Maureen C. Hatch; Chien-Jen Chen; Bruce Levin; Bu-Tian Ji; Guang-Yang Yang; Shang-Wei Hsu; Lian-Wen Wang; Ling-Ling Hsieh; Regina M. Santella
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1993
- Language
- EN
- Field
- Medicine (Health Sciences)