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Excessive Volume Expansion and Neonatal Death in Preterm Infants Born at 27–28 Weeks Gestation by Andrew K. Ewer; Wendy Tyler; Andre Francis; Donna Drinkall; Jason O. Gardosi is a Medicine article available to read on EtoBox.

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## Summary Volume expansion is used commonly in preterm infants to treat presumed hypovolaemia. However, the amount that should be given is uncertain. We present data that were obtained from anonymised regional case notes of Project 27/28, a national case–controlled study run by the Confidential Enquiry into Stillbirths and Deaths in Infancy. Various clinical parameters were analysed, including the volume expansion administered during the first 48 h of life. All deaths in the first year of the study in the West Midlands (cases, __n__ = 22) and matched regional controls (survivors, __n__ = 29) were included. The primary outcome was death within 28 days. Sixteen of the 22 deaths were considered ‘not inevitable’ on the basis of the neonates’ condition at birth. These newborns received on average more than twice the volume expansion compared with controls in the first 48 h of life (38.2 vs. 18.2 mL/kg, __P__ = 0.007). There were no significant differences between the groups in lowest blood pressure or base deficit within the first 12 h of life. Newborns who received ≥ 30 mL/kg volume expansion in the first 48 h of life were more likely to die than those who received < 30 mL/kg (OR 4.5

Who reads Excessive Volume Expansion and Neonatal Death in Preterm Infants Born at 27–28 Weeks Gestation?

Author

Andrew K. Ewer; Wendy Tyler; Andre Francis; Donna Drinkall; Jason O. Gardosi

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0269-5022)

Published

2003

Language

EN

Field

Medicine (Health Sciences)