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Reduction of the Nociceptive Response to Gastric Distension by Nitrate Ingestion in Rats by Rouzade; Anton; Fioramonti; Garcia‐Villar; Theodorou; Bueno is a Medicine article available to read on EtoBox.

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## Background : Dietary nitrates are known to produce nitric oxide in the stomach, which may influence gastric function. ## Aim : To investigate whether nitrate ingestion modifies gastric sensitivity to distension through a mechanism involving nitric oxide production. ## Methods : Nociception, associated with gastric distension ranging from 10 to 40 mmHg, was assessed in anaesthetized rats by the amplitude of cardiovascular depressor responses. Gastric volume corresponding to each distension was recorded. The following intragastric administrations (1 mL) were performed before distension: water (control), KNO~3~, NaNO~3~, KCl, NaCl (all at 0.1 mmol/kg), standard food (0.5 g), sodium nitroprusside, a nitric oxide donor (5 mg/kg), and haemoglobin, a nitric oxide scavenger (150 mg/kg) given either with water or KNO~3~. ## Results : In controls, the fall in blood pressure increased from 7.8 ± 2.0 to 31.6 ± 2.7 mmHg at distending pressures from 10 to 40 mmHg, respectively. KNO~3~ significantly reduced the amplitude of blood pressure response for the highest distending pressures (35 and 40 mmHg), while KCl induced a reduction in blood pressure response at all gastric pressures. NaNO~3~ an

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Author

Rouzade; Anton; Fioramonti; Garcia‐Villar; Theodorou; Bueno

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

1999

Language

EN

Field

Medicine (Health Sciences)