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Are multifocal motor neuropathy and Lewis–Sumner syndrome distinct nosologic entities? by Gareth J. Parry is a Medicine article available to read on EtoBox.

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In 1982, Lewis and colleagues 7 described an unusual neuropathy which could best be characterized as a demyelinating mononeuropathy multiplex. Patients developed slowly evolving neurological deficits in a restricted distribution, within the territory of individual peripheral nerves. In all five patients, these deficits involved both sensory and motor functions, although the latter predominated. The disorder was very chronic, with symptoms evolving over more than 20 years in one patient. Deficits were most prominent in the upper extremities. The authors regarded this neuropathy as a variant of chronic inflammatory demyelinating neuropathy (CIDP); the principal feature that set it apart from typical CIDP was the nature and distribution of the electrophysiological findings. In each patient there was severe motor conduction block that was restricted to quite short segments of affected nerves; motor conduction in intervening segments was relatively preserved. Furthermore, the conduction block was persistent, remaining unchanged in severity and distribution for periods as long as 3 years. Sensory conduction studies were abnormal in all patients but, in keeping with the clinical picture,

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Author

Gareth J. Parry

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0148-639X)

Published

1999

Language

EN

Field

Medicine (Health Sciences)