Can I read Therapeutics effects of [Pyr1] apelin-13 on rat contusion model of spinal cord injury: An experimental study on EtoBox?

Therapeutics effects of [Pyr1] apelin-13 on rat contusion model of spinal cord injury: An experimental study by Saeed Vafaei-Nezhad; Somayeh Niknazar; Mohsen Norouzian; Mohammad-Amin Abdollahifar; Abbas Aliaghaei; Hojjat Allah Abbaszadeh is a Neuroscience article available to read on EtoBox.

What is Therapeutics effects of [Pyr1] apelin-13 on rat contusion model of spinal cord injury: An experimental study about?

Spinal cord injury (SCI) can cause various symptoms, including pain, complete or incomplete loss of autonomic, sensory, motor and functions inferior to the site of the damage. Despite wondrous advances in medicine, treating spinal cord injuries remains a thorny issue yet. Recently, the control of inflammatory processes after damage to the nervous system has been noticed as a promising therapeutic target. The goal of the present experiment was to identify the effects of apelin-13 on the histological outcome, inflammatory factors, and functional recovery in the animal contusion model of SCI were analyzed. 40 Female Wistar rats were randomly but equally assigned in laminectomy, contusion, PBS (1 mL PBS, i.p), control group which received apelin-13 (control + apelin, 100 μg/kg, i.p), and apelin-13 treatment groups. In the treatment group, apelin-13 (100 μg/kg) was injected intraperitoneally 30 min after injury. The weight-dropping contusion model was used for inducing SCI. The Basso, Beattie, and Bresnahan scale (BBB), narrow beam test (NBT), rotarod test, and the open-field test was applied to evaluate locomotor and behavioral activity. Real-time polymerase chain reaction (PCR) and EL

Who reads Therapeutics effects of [Pyr1] apelin-13 on rat contusion model of spinal cord injury: An experimental study?

Author

Saeed Vafaei-Nezhad; Somayeh Niknazar; Mohsen Norouzian; Mohammad-Amin Abdollahifar; Abbas Aliaghaei; Hojjat Allah Abbaszadeh

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Neuroscience (Life Sciences)