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Induction of CCK mRNA levels in the limbic-hypothalamic circuit: Time course and site-specific effects of estrogen by Paul Micevych; Clair B. Eckersell; Krista Holland; Akemi Smith is a Neuroscience article available to read on EtoBox.

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Estrogenic regulation of cholecystokinin (CCK) and its receptors is correlated with the initiation and termination of lordosis behavior. To understand the effect of circulating estrogen concentration on the temporal aspects of CCK mRNA expression in the posterodorsal medial amygdaloid nucleus (MeApd) and the central part of the medial preoptic nucleus ( M P N c ) of the limbic-hypothalamic circuit, ovariectomized female rats were treated with a 10 mm SilasticTM capsule filled with estradiol, a bolus injection of 50 pg estradiol benzoate or 2 pg estradiol benzoate every 4 days for five "cycles." In situ hybridization was used to compare the relative changes of CCK mRNA levels a t 0 h to levels measured at 6,12,24, 48, 72, or 96 h after estrogen administration. In the M P N c and the MeApd, the 10-mm capsule significantly increased and maintained CCK mRNA levels from 6 to 96 h. The range of the increase was 3.0-5.1-fold in the M P N c and 2.8-5.0 in the MeApd. The 50-pg injections significantly increased and maintained CCK mRNA levels in the MPNc from 1 2 to 96 h (range of the increase 2.4-4.1-fold) and in the MeApd from 24 to 96 h (range of the increase 2.2-2.8-fold). The repeated a

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Author

Paul Micevych; Clair B. Eckersell; Krista Holland; Akemi Smith

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3034)

Published

1996

Language

EN

Field

Neuroscience (Life Sciences)