Can I read Uptake of Cobalamin and Markers of Cobalamin Status: a Longitudinal Study of Healthy Pregnant Women on EtoBox?

Uptake of Cobalamin and Markers of Cobalamin Status: a Longitudinal Study of Healthy Pregnant Women by Eva Greibe; Birgitte Horst Andreasen; Dorte L. Lildballe; Anne L. Morkbak; Anne-Mette Hvas; Ebba Nexo is a Medicine article available to read on EtoBox.

What is Uptake of Cobalamin and Markers of Cobalamin Status: a Longitudinal Study of Healthy Pregnant Women about?

## Background: Currently, it is unknown whether the decline in plasma cobalamin observed during pregnancy is caused by malabsorption of the vitamin. this study examined cobalamin absorption and markers of cobalamin status during normal pregnancy. ## Methods: Twenty-seven pregnant danish women were examined at gestation weeks 13, 24 and 36. the absorption test cobasorb was performed in all women implying measurement of holotranscobalamin or cyanocobalamin bound to transcobalamin before and after 2 days intake of 3 × 9 μg cobalamin. serum cobalamin and the two cobalamin binding proteins transcobalamin and haptocorrin, including haptocorrin saturated with cobalamin or analogues, were measured, and so was plasma methylmalonic acid and homocysteine. ## Results: No change in the uptake of cobalamin was observed throughout pregnancy. serum cobalamin displayed a gradual decline during pregnancy (p<0.0001), while holotranscobalamin remained unchanged, despite an increase in total transcobalamin (p<0.0001). in accord with these results, total haptocorrin showed a decline from the 1st to 3rd trimester (p=0.007) and cobalamin bound to haptocorrin declined (p<0.0001). interestingly, the amount

Who reads Uptake of Cobalamin and Markers of Cobalamin Status: a Longitudinal Study of Healthy Pregnant Women?

Author

Eva Greibe; Birgitte Horst Andreasen; Dorte L. Lildballe; Anne L. Morkbak; Anne-Mette Hvas; Ebba Nexo

Publisher

Walter de Gruyter GmbH

Published

2011

Language

EN

Field

Medicine (Health Sciences)