Can I read An Isolated Perfused Pig Heart Model for the Development, Validation and Translation of Novel Cardiovascular Magnetic Resonance Techniques on EtoBox?

An Isolated Perfused Pig Heart Model for the Development, Validation and Translation of Novel Cardiovascular Magnetic Resonance Techniques by Andreas Schuster; Inga Grünwald; Amedeo Chiribiri; Richard Southworth; Masaki Ishida; Gunnar Hay; Nicole Neumann; Geraint Morton; Divaka Perera; Tobias Schaeffter; Eike Nagel is a Medicine article available to read on EtoBox.

What is An Isolated Perfused Pig Heart Model for the Development, Validation and Translation of Novel Cardiovascular Magnetic Resonance Techniques about?

## Abstract ## Background Novel cardiovascular magnetic resonance (CMR) techniques and imaging biomarkers are often validated in small animal models or empirically in patients. Direct translation of small animal CMR protocols to humans is rarely possible, while validation in humans is often difficult, slow and occasionally not possible due to ethical considerations. The aim of this study is to overcome these limitations by introducing an MR-compatible, free beating, blood-perfused, isolated pig heart model for the development of novel CMR methodology. ## Methods 6 hearts were perfused outside of the MR environment to establish preparation stability. Coronary perfusion pressure (CPP), coronary blood flow (CBF), left ventricular pressure (LVP), arterial blood gas and electrolyte composition were monitored over 4 hours. Further hearts were perfused within 3T (n = 3) and 1.5T (n = 3) clinical MR scanners, and characterised using functional (CINE), perfusion and late gadolinium enhancement (LGE) imaging. Perfusion imaging was performed globally and selectively for the right (RCA) and left coronary artery (LCA). In one heart the RCA perfusion territory was determined and compared to infa

Who reads An Isolated Perfused Pig Heart Model for the Development, Validation and Translation of Novel Cardiovascular Magnetic Resonance Techniques?

Author

Andreas Schuster; Inga Grünwald; Amedeo Chiribiri; Richard Southworth; Masaki Ishida; Gunnar Hay; Nicole Neumann; Geraint Morton; Divaka Perera; Tobias Schaeffter; Eike Nagel

Publisher

BioMed Central; Springer (Biomed Central Ltd.); New York NY: Marcel Dekker; New York N.Y.: Informa Healthcare; London: 2008-; Informa UK Limited; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1097-6647)

Published

2010

Language

EN

Field

Medicine (Health Sciences)