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Primary and secondary nonrandom X chromosome inactivation in early female mouse embryos carrying Searle's translocation T(X; 16)16H by Nobuo Takagi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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By means of a cytological technique involving 5-bromodeoxyuridine, acridine orange, and fluorescence microscopy, the asynchronously replicating, hence genetically inactivated, X chromosome was identified in 6to 8-day embryos from female mice heterozygous for Searle's translocation T(X;16)16H (abbreviated as T16H) mated with either karyotypically normal males or males carrying Cattanach's translo cation T(X ;7)1 Ct in order to analyse the way in which the total inactivation of the normal X is achieved in adult T16H heterozygotes. Embryos examined included 9 xn/x{7);16/16, 3 XI~/Xn; 16~/16, 12 X16/X{V); 16~/16, 5 X16/Xn; 16/16, 8 X16/X(~); 16/16 and 2 Xn/Y; 16~/16/16. In these notations X t6, 16 x, X (7) and X n represent Searle's X with the centromeric segment of the X, Searle's X with the centomeric segment of chromosome 16, Cattanachs's X with insertion of a chromosome 7 segment, and normal X, respectively. The X (7) exerted no apparent effect upon embryonic development up to the 8th day of gestation and X chromosome inactivation. -The asynchronously replicating X was the X n in X~6/ Xn; 16x/16 and X {7) in X16/X{7);16• embryos except a small number of cells on day 6 (13/493) and

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Author

Nobuo Takagi

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0009-5915)

Published

1980

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)