Opening book details…
Can I read Total synthesis of a biotinylated derivative of phorboxazole A via sonogashira coupling on EtoBox?
Total synthesis of a biotinylated derivative of phorboxazole A via sonogashira coupling by T.Matthew Hansen; Mary M. Engler; Craig J. Forsyth is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Total synthesis of a biotinylated derivative of phorboxazole A via sonogashira coupling about?
The C46 terminus of phorboxazole A has been modified to incorporate a biotin-terminated linker via direct palladium-mediated Sonogashira reaction conditions. Synthetic 45,46-dehydrobromophorboxazole A was joined with a tris-(polyethyleneglycol)vinyl iodide-biotin ester using catalytic PdCl(2)(PPh(3))(2), CuI, and Et(3)N in THF. This process demonstrates the utility of mild carbon-carbon bond formation in the context of phorboxazoles' architecture and provides a potential affinity probe.
Who reads Total synthesis of a biotinylated derivative of phorboxazole A via sonogashira coupling?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- T.Matthew Hansen; Mary M. Engler; Craig J. Forsyth
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2003
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)