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What is T Cell Exhaustion in Immunotherapy about?

This document discusses cell-intrinsic barriers to T cell-based immunotherapy. It describes how prolonged exposure of CD8+ T cells to antigens can lead to T cell exhaustion, repressing effector functions. Recent advances using immune checkpoint blockade have helped rejuvenate effector functions against some cancers. However, it is unclear if this approach leads to long-lasting antitumor immunity. Emerging evidence suggests T cell exhaustion may also limit the effectiveness of chimeric antigen receptor T cel

Author

ro111111

Language

EN