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Can I read Angiofil®-mediated visualization of the vascular system by microcomputed tomography: A feasibility study on EtoBox?
Angiofil®-mediated visualization of the vascular system by microcomputed tomography: A feasibility study by Silke Grabherr; Andreas Hess; Marek Karolczak; Michael J. Thali; Sebastian D. Friess; Willi A. Kalender; Richard Dirnhofer; Valentin Djonov is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Angiofil®-mediated visualization of the vascular system by microcomputed tomography: A feasibility study about?
## Abstract Visualization of the vascular systems of organs or of small animals is important for an assessment of basic physiological conditions, especially in studies that involve genetically manipulated mice. For a detailed morphological analysis of the vascular tree, it is necessary to demonstrate the system in its entirety. In this study, we present a new lipophilic contrast agent, Angiofil®, for performing postmortem microangiography by using microcomputed tomography. The new contrast agent was tested in 10 wild‐type mice. Imaging of the vascular system revealed vessels down to the caliber of capillaries, and the digital three‐dimensional data obtained from the scans allowed for virtual cutting, amplification, and scaling without destroying the sample. By use of computer software, parameters such as vessel length and caliber could be quantified and remapped by color coding onto the surface of the vascular system. The liquid Angiofil® is easy to handle and highly radio‐opaque. Because of its lipophilic abilities, it is retained intravascularly, hence it facilitates virtual vessel segmentation, and yields an enduring signal which is advantageous during repetitive investigations,
Who reads Angiofil®-mediated visualization of the vascular system by microcomputed tomography: A feasibility study?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Silke Grabherr; Andreas Hess; Marek Karolczak; Michael J. Thali; Sebastian D. Friess; Willi A. Kalender; Richard Dirnhofer; Valentin Djonov
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1059-910X)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)