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Graphene Oxide Coated Three-dimensional Printed Biphasic Calcium Phosphate Scaffold for Angiogenic and Osteogenic Synergy in Repairing Critical-size Bone Defect by Yitian Wang; Yonghao Wu; Yuqi Zhang; Xiangfeng Li; Li Min; Quanle Cao; Yi Luo; Xiao Yang; Minxun Lu; Yong Zhou; Xiangdong Zhu; Chongqi Tu; Xingdong Zhang is a Engineering article available to read on EtoBox.

What is Graphene Oxide Coated Three-dimensional Printed Biphasic Calcium Phosphate Scaffold for Angiogenic and Osteogenic Synergy in Repairing Critical-size Bone Defect about?

The custom-tailored medicine requires a developmental strategy that integrates excellent osteogenesis with mechanical stability to enhance the reconstruction of the critical-size bone defect (CSBD) and the healing process in weight-bearing bone. We prepared three-dimensional (3D) printed biphasic calcium phosphate (BCP) scaffolds composited with nano-graphene oxide (GO). The biological effects of the GO/BCP composite scaffolds could induce the differentiation of rat bone marrow stem cells (BMSCs) and the migration of human umbilical vein endothelial cells (HUVECs) for bone repair. The proper ratio of GO in the composite scaffold regulated the composites’ surface roughness and hydrophilicity to a suitable range for the adhesion and proliferation of BMSCs and HUVECs. Besides, the GO/BCP composite scaffold increased osteogenesis and angiogenesis by activating BMP-2, RUNX-2, Smad1/4, and VEGF. The customized intramedullary nail combined with GO/BCP scaffold was applied to repair CSBD (2.0 cm in length) in a beagle femur model. This fixation strategy was confirmed by finite element analysis. In vivo, the results indicated that the custom-made internal fixation provided sufficient stabil

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Author

Yitian Wang; Yonghao Wu; Yuqi Zhang; Xiangfeng Li; Li Min; Quanle Cao; Yi Luo; Xiao Yang; Minxun Lu; Yong Zhou; Xiangdong Zhu; Chongqi Tu; Xingdong Zhang

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Engineering (Physical Sciences)