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The Effect of Intraocular 6-Hydroxydopamine on Retinal Processing of Primates by Maria Felice Ghilardi; Marcia S. Marx; Dr. Ivan Bodis-Wollner; Carl B. Camras; Andrew A. Glover is a Medicine article available to read on EtoBox.

What is The Effect of Intraocular 6-Hydroxydopamine on Retinal Processing of Primates about?

In previous studies, we showed that in the monkey, systemically administered N-methyl, 4-phenyl, 1-2-3-6 tetrahydropyridine (MPTP) produces a chronic parkinsonian syndrome accompanied by spatial frequency-dependent abnormalities in both the pattern electroretinogram and visual evoked potential. We describe the effect of intravitreally administered 6-hydroxydopamine (6-OH-DA) on the pattern electroretinogram and pattern visual evoked potential of 3 aphakic monkeys. Because of the aphake condition, several complexities of intravitreal injection of GOH-DA couid be avoided. Nevenheless, following 6-OH-DA treatment, both the phase and the amplitude of pattern electroretinogram and pattern visual evoked potential became abnormal. This abnormality was most pronounced for the higher spatial frequencies (2.5 and 3.5 cycles per degree), whereas lower spatial frequencies (0.5 and 1.2 cycles per degree) were less impaired. The effects of systemically administered MPTP on pattern eiectroretinogram and pattern visual evoked potential are similar to the effects of intravitreal injections of &OH-DA, suggesting that a retinal catecholaminergic system piays an important role in pattern vision of pri

Who reads The Effect of Intraocular 6-Hydroxydopamine on Retinal Processing of Primates?

Author

Maria Felice Ghilardi; Marcia S. Marx; Dr. Ivan Bodis-Wollner; Carl B. Camras; Andrew A. Glover

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0364-5134)

Published

1989

Language

EN

Field

Medicine (Health Sciences)