Opening book details…
Can I read A NEW CHONDRODYSTROPHIC MUTANT IN MICE: Electron Microscopy of Normal and Abnormal Chondrogenesis on EtoBox?
A NEW CHONDRODYSTROPHIC MUTANT IN MICE: Electron Microscopy of Normal and Abnormal Chondrogenesis by R. Seegmiller; F. C. Fraser; H. Sheldon is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A NEW CHONDRODYSTROPHIC MUTANT IN MICE: Electron Microscopy of Normal and Abnormal Chondrogenesis about?
The occurrence of a new mutation affecting cartilage and bone in mice is reported. The gene is lethal, shows autosomal recessive inheritance, and has high penetrance. It is not allelic to __shorthead__ and probably not to __phocomelia__ or __achondroplasia__. It results in a foreshortened face, cleft palate, defective trachea, and shortened long bones with flared metaphyses. Chondrocytes of epiphyseal cartilage from the mutant are not aligned in columns, and there is a decrease in the usual staining of the cartilage matrix. Electron microscope observations show large, wide collagen fibrils with "native" banding in the matrix of mutant cartilage, which are not present in normal cartilage. Possible explanations for the expression of this genetic disorder of cartilage development are put forward.
Who reads A NEW CHONDRODYSTROPHIC MUTANT IN MICE: Electron Microscopy of Normal and Abnormal Chondrogenesis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- R. Seegmiller; F. C. Fraser; H. Sheldon
- Publisher
- Rockefeller University Press.; The Rockefeller University Press; Rockefeller University Press; ScienceOpen (ISSN 0021-9525)
- Published
- 1971
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)