Can I read The PE-PPE Family of Mycobacterium tuberculosis: Proteins in Disguise on EtoBox?

The PE-PPE Family of Mycobacterium tuberculosis: Proteins in Disguise by Christopher D'Souza; Uday Kishore; Anthony G. Tsolaki is a Immunology and Microbiology article available to read on EtoBox.

What is The PE-PPE Family of Mycobacterium tuberculosis: Proteins in Disguise about?

Mycobacterium tuberculosis has thrived in parallel with humans for millennia, and despite our efforts, M. tuberculosis continues to plague us, currently infecting a third of the world’s population. The success of M. tuberculosis has recently been attributed, in part, to the PE-PPE family; a unique collection of 168 proteins fundamentally involved in the pathogenesis of M. tuberculosis. The PE-PPE family proteins have been at the forefront of intense research efforts since their discovery in 1998 and whilst our knowledge and understanding has significantly advanced over the last two decades, many important questions remain to be elucidated. This review consolidates and examines the vast body of existing literature regarding the PE-PPE family proteins, with respect to the latest developments in elucidating their evolution, structure, subcellular localisation, function, and immunogenicity. This review also highlights significant inconsistencies and contradictions within the field. Additionally, possible explanations for these knowledge gaps are explored. Lastly, this review poses many important questions, which need to be addressed to complete our understanding of the PE-PPE family, a

Who reads The PE-PPE Family of Mycobacterium tuberculosis: Proteins in Disguise?

Author

Christopher D'Souza; Uday Kishore; Anthony G. Tsolaki

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Immunology and Microbiology (Life Sciences)