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## Etoricoxib/methotrexate interaction Various toxicities: case report A 48-year-old man developed acute methotrexate toxicity in the form of pancytopenia, ulcerations, nausea, vomiting, diarrhoea, worsening of chronic plaque psoriasis and worsening of renal function following concomitant administration of methotrexate for chronic plaque psoriasis and etoricoxib for arthralgia [routes not stated]. The man was admitted to the emergency department with chief complaints of extensive oral and genital erosions, intermittent fever and ulcerations (both type 1 and 2) over the red, scaly lesions on palm and soles for duration of 5 days. His medical history was significant for arthralgia involving the lower back, bilateral shoulder and knee joints for the last 5 years, for which he had been receiving treatment with etoricoxib 90mg daily for the same duration. He also had hypertension, diabetes and hypertensive nephropathy, and he was not compliant to his treatment. He also had chronic plaque psoriasis for 4 years. He had been receiving unspecified steroids and emollients for skin lesions. Eight days prior to his admission, he received a single dose of methotrexate 15mg as advised by a priva

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Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)