Opening book details…
Can I read Synthesis of 7- and 10-Spermine Conjugates of Paclitaxel and 10-Deacetyl-paclitaxel as Potential Prodrugs on EtoBox?
Synthesis of 7- and 10-Spermine Conjugates of Paclitaxel and 10-Deacetyl-paclitaxel as Potential Prodrugs by Arturo Battaglia; Andrea Guerrini; Eleonora Baldelli; Gabriele Fontana; Greta Varchi; Cristian Samorì; Ezio Bombardelli is a Chemistry article available to read on EtoBox.
What is Synthesis of 7- and 10-Spermine Conjugates of Paclitaxel and 10-Deacetyl-paclitaxel as Potential Prodrugs about?
Efficient syntheses of two taxol analogs bearing the linear polyamine spermine at 7-and 10-positions of paclitaxel and 10deacetyl-paclitaxel have been developed. These polyamine-taxol-conjugates were isolated as water soluble difluoride salts. The aim of the present work was to introduce a chemical modification into taxol skeleton in order to increase drug selectivity toward tumor cells. The cytotoxic activity of these conjugates was evaluated in MCF7 and MCF7-R cell lines. The observed low cytotoxicity suggests that these conjugates could act as potential prodrugs.
Who reads Synthesis of 7- and 10-Spermine Conjugates of Paclitaxel and 10-Deacetyl-paclitaxel as Potential Prodrugs?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Arturo Battaglia; Andrea Guerrini; Eleonora Baldelli; Gabriele Fontana; Greta Varchi; Cristian Samorì; Ezio Bombardelli
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)
- Published
- 2006
- Language
- EN
- Field
- Chemistry (Physical Sciences)