Can I read Relaxant Effects of Antidepressants on Human Isolated Mesenteric Arteries on EtoBox?

Relaxant Effects of Antidepressants on Human Isolated Mesenteric Arteries by José M. Vila; Pascual Medina; Gloria Segarra; Paloma Lluch; Federico Pallardó; Blas Flor; Salvador Lluch is a Medicine article available to read on EtoBox.

What is Relaxant Effects of Antidepressants on Human Isolated Mesenteric Arteries about?

__Aims__ The therapeutic action of tricyclic agents may be accompanied by unwanted effects on the cardiovascular system. The evidence for the effects on vascular and nonvascular smooth muscle comes from animal studies. Whether these studies can be extrapolated to human vessels remains to be determined. Therefore, the present study was designed to investigate the influence of amitriptyline, nortriptyline and sertraline on the contractile responses of human isolated mesenteric arteries to electrical field stimulation, noradrenaline and potassium chloride. __Methods__ Arterial segments (lumen diameter 0.8–1.2 mm) were obtained from portions of the human omentum during the course of 41 abdominal operations (22 men and 19 women), and rings 3 mm long were mounted in organ baths for isometric recording of tension. In some artery rings the endothelium was removed mechanically. __Results In precontracted artery rings amitriptyline, nortriptyline and sertraline (3×10^−7^–10^−4^ m ) produced concentration‐dependent relaxation that was independent of the presence or absence of vascular endothelium. Incubation with indomethacin (3×10^−6^ m ) reduced the pD~2~ values thus indicating the particip

Who reads Relaxant Effects of Antidepressants on Human Isolated Mesenteric Arteries?

Author

José M. Vila; Pascual Medina; Gloria Segarra; Paloma Lluch; Federico Pallardó; Blas Flor; Salvador Lluch

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)

Published

1999

Language

EN

Field

Medicine (Health Sciences)