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Functions and Mechanisms of Adenosine and Its Receptors in Sleep Regulation by Lishan Huang; Wenwen Zhu; Nanxi Li; Bin Zhang; Wenbin Dai; Sen Li; Houping Xu is a Medicine article available to read on EtoBox.

What is Functions and Mechanisms of Adenosine and Its Receptors in Sleep Regulation about?

Sleep is a natural and recurring state of life. Long-term insomnia can lead to physical and mental fatigue, inattention, memory loss, anxiety, depression and other symptoms, imposing immense public health and economic burden worldwide. The sleep and awakening regulation system is composed of many nerve nuclei and neurotransmitters in the brain, and it forms a neural network that interacts and restricts each other to regulate the occurrence and maintenance of sleep-wake. Adenosine (AD) is a neurotransmitter in the central nervous system and a driver of sleep. Meanwhile, the functions and mechanisms underlying sleep-promoting effects of adenosine and its receptors are still not entirely clear. However, in recent years, the increasing evidence indicated that adenosine can promote sleep through inhibiting arousal system and activating sleep-promoting system. At the same time, astrocyte-derived adenosine in modulating sleep homeostasis and sleep loss-induced related cognitive and memory deficits plays an important role. This review, therefore, summarizes the current research on the functions and possible mechanisms of adenosine and its receptors in the regulation of sleep and homeostati

Who reads Functions and Mechanisms of Adenosine and Its Receptors in Sleep Regulation?

Author

Lishan Huang; Wenwen Zhu; Nanxi Li; Bin Zhang; Wenbin Dai; Sen Li; Houping Xu

Publisher

Elsevier BV

Published

2024

Language

EN

Field

Medicine (Health Sciences)