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Can I read Steroidogenic Acute Regulatory Protein (StAR): Evidence of Gonadotropin-Induced Steroidogenesis in Alzheimer Disease on EtoBox?
Steroidogenic Acute Regulatory Protein (StAR): Evidence of Gonadotropin-Induced Steroidogenesis in Alzheimer Disease by Kate M Webber; Douglas M Stocco; Gemma Casadesus; Richard L Bowen; Craig S Atwood; Laura A Previll; Peggy LR Harris; Xiongwei Zhu; George Perry; Mark A Smith is a Medicine article available to read on EtoBox.
What is Steroidogenic Acute Regulatory Protein (StAR): Evidence of Gonadotropin-Induced Steroidogenesis in Alzheimer Disease about?
## Background Alzheimer disease (AD) is clinically characterized by progressive memory loss, impairments in behavior, language and visual-spatial skills and ultimately, death. Epidemiological data reporting the predisposition of women to AD has led to a number of lines of evidence suggesting that age-related changes in hormones of the hypothalamic-pituitary-gonadal (HPG) axis following reproductive senescence, may contribute to the etiology of AD. Recent studies from our group and others have reported not only increases in circulating gonadotropins, namely luteinizing hormone (LH) in individuals with AD compared with control individuals, but also significant elevations of LH in vulnerable neuronal populations in individuals with AD compared to control cases as well as the highest density of gonadotropin receptors in the brain are found within the hippocampus, a region devastated in AD. However, while LH is higher in AD patients, the downstream consequences of this are incompletely understood. To begin to examine this issue, here, we examined the expression levels of steroidogenic acute regulatory (StAR) protein, which regulates the first key event in steroidogenesis, namely, the tr
Who reads Steroidogenic Acute Regulatory Protein (StAR): Evidence of Gonadotropin-Induced Steroidogenesis in Alzheimer Disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Kate M Webber; Douglas M Stocco; Gemma Casadesus; Richard L Bowen; Craig S Atwood; Laura A Previll; Peggy LR Harris; Xiongwei Zhu; George Perry; Mark A Smith
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2006-; Springer Science and Business Media LLC (ISSN 1750-1326)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)