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Paclitaxel combined with fractionated radiation in vitro: A study with vulvar squamous cell carcinoma cell lines by Misa Raitanen; Virpi Rantanen; Jarmo Kulmala; Jaakko Pulkkinen; Pekka Klemi; Seija Grénman; Reidar Grénman is a Medicine article available to read on EtoBox.
What is Paclitaxel combined with fractionated radiation in vitro: A study with vulvar squamous cell carcinoma cell lines about?
## Abstract Concurrent paclitaxel and radiation has given promising results in the treatment of a variety of solid tumors. We wanted to test the efficacy of this combination for vulvar carcinoma, which currently has a poor outcome in advanced stages. The radiation sensitivity, sublethal damage repair (SLDR) capacity and effect of paclitaxel during fractionated radiation were assessed in our study on 7 vulvar inherently radioresistant squamous cell carcinoma (SCC) cell lines. The 96‐well plate clonogenic assay was used. Survival data were fitted to the linear quadratic model. The area under the curve (AUC), equivalent to mean inactivation dose (D̄), was obtained with numerical integration. AUC ratios between single‐dose radiation and fractionated radiation with or without paclitaxel were used to determine the SLDR of the cell lines and the effect of paclitaxel on it. Seven currently tested vulvar SCC cell lines were found to have a limited capacity of repairing sublethal damage (SLD). Only 3 of them presented SLDR of significance. The effect of concurrent radiation and paclitaxel was clearly additive when the radiation dose was fractionated in most of the cell lines. In addition, 2
Who reads Paclitaxel combined with fractionated radiation in vitro: A study with vulvar squamous cell carcinoma cell lines?
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- Author
- Misa Raitanen; Virpi Rantanen; Jarmo Kulmala; Jaakko Pulkkinen; Pekka Klemi; Seija Grénman; Reidar Grénman
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)