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In vitro and ex vivo antimycobacterial potential of azole drugs against Mycobacterium tuberculosis H~37~Rv by Zahoor Ahmad; Sadhna Sharma; G.K. Khuller is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is In vitro and ex vivo antimycobacterial potential of azole drugs against Mycobacterium tuberculosis H~37~Rv about?

The antimycobacterial activity of two clinically approved antifungal azole drugs, clotrimazole and econazole, was evaluated against Mycobacterium tuberculosis H 37 Rv under in vitro and ex vivo conditions. The minimum inhibitory concentration (MIC 90 ) was 0.120 lg ml À1 , whereas the minimum bactericidal concentration and effective concentration was 0.125 lg ml À1 for both the drugs demonstrating their potent antimycobacterial activity. Further, the azole drugs exhibited a synergistic activity with either rifampicin or isoniazid as evaluated on the basis of reduction of colony forming units. The results suggest that azole compounds bear the potential to enhance the efficacy of currently prescribed antitubercular drugs.

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Author

Zahoor Ahmad; Sadhna Sharma; G.K. Khuller

Publisher

John Wiley and Sons; Oxford University Press; Oxford University Press (OUP); Elsevier BV (ISSN 0378-1097)

Published

2005

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)