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Can I read Gelatin Methacryloyl-alginate Core-shell Microcapsules as Efficient Delivery Platforms for Prevascularized Microtissues in Endodontic Regeneration on EtoBox?
Gelatin Methacryloyl-alginate Core-shell Microcapsules as Efficient Delivery Platforms for Prevascularized Microtissues in Endodontic Regeneration by Xi Liang; Li Xie; Qingyuan Zhang; Ge Wang; Siyuan Zhang; Mingyan Jiang; Ruitao Zhang; Ting Yang; Xingyu Hu; Ziyang Yang; Weidong Tian is a Engineering article available to read on EtoBox.
What is Gelatin Methacryloyl-alginate Core-shell Microcapsules as Efficient Delivery Platforms for Prevascularized Microtissues in Endodontic Regeneration about?
Combined injectable cell-laden microspheres and angiogenesis approaches are promising for functional vascularized endodontic regeneration. However, advanced microsphere designs and production techniques that benefit practical applications are rarely developed. Herein, gelatin methacryloyl (GelMA)-alginate core-shell microcapsules were fabricated to co-encapsulate human dental pulp stem cells (hDPSCs) and human umbilical vein endothelial cells (HUVECs) based on a coaxial electrostatic microdroplet technique. This technique enables high-throughput production, convenient collection, and minimal material waste. The average diameter of core-shell microcapsules was ∼359 μm, and that of GelMA cores was ∼278 μm. There were higher proliferation rates for hDPSCs and HUVECs co-encapsulated in the GelMA cores than for hDPSCs or HUVECs monoculture group. HUVECs assembled to form 3D capillary-like networks in co-culture microcapsules. Moreover, HUVECs promoted the osteo/odontogenic differentiation of hDPSCs in microcapsules. After 14 days of cultivation, prevascularized microtissues formed in microcapsules that contained abundant deposited extracellular matrix (ECM); no microcapsule aggregation
Who reads Gelatin Methacryloyl-alginate Core-shell Microcapsules as Efficient Delivery Platforms for Prevascularized Microtissues in Endodontic Regeneration?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Xi Liang; Li Xie; Qingyuan Zhang; Ge Wang; Siyuan Zhang; Mingyan Jiang; Ruitao Zhang; Ting Yang; Xingyu Hu; Ziyang Yang; Weidong Tian
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)