Can I read A multifunctional platform with single-NIR-laser-triggered photothermal and NO release for synergistic therapy against multidrug-resistant Gram-negative bacteria and their biofilms on EtoBox?

A multifunctional platform with single-NIR-laser-triggered photothermal and NO release for synergistic therapy against multidrug-resistant Gram-negative bacteria and their biofilms by Zhao, Baohua; Wang, He; Dong, Wenjing; Cheng, Shaowen; Li, Haisheng; Tan, Jianglin; Zhou, Junyi; He, Weifeng; Li, Lanlan; Zhang, Jianxiang; Luo, Gaoxing; Qian, Wei is a Engineering article available to read on EtoBox.

What is A multifunctional platform with single-NIR-laser-triggered photothermal and NO release for synergistic therapy against multidrug-resistant Gram-negative bacteria and their biofilms about?

## Background Infectious diseases caused by multidrug-resistant (MDR) bacteria, especially MDR Gram-negative strains, have become a global public health challenge. Multifunctional nanomaterials for controlling MDR bacterial infections via eradication of planktonic bacteria and their biofilms are of great interest. ## Results In this study, we developed a multifunctional platform (TG-NO-B) with single NIR laser-triggered PTT and NO release for synergistic therapy against MDR Gram-negative bacteria and their biofilms. When located at the infected sites, TG-NO-B was able to selectively bind to the surfaces of Gram-negative bacterial cells and their biofilm matrix through covalent coupling between the BA groups of TG-NO-B and the bacterial LPS units, which could greatly improve the antibacterial efficiency, and reduce side damages to ambient normal tissues. Upon single NIR laser irradiation, TG-NO-B could generate hyperthermia and simultaneously release NO, which would synergistically disrupt bacterial cell membrane, further cause leakage and damage of intracellular components, and finally induce bacteria death. On one hand, the combination of NO and PTT could largely improve the antib

Who reads A multifunctional platform with single-NIR-laser-triggered photothermal and NO release for synergistic therapy against multidrug-resistant Gram-negative bacteria and their biofilms?

Author

Zhao, Baohua; Wang, He; Dong, Wenjing; Cheng, Shaowen; Li, Haisheng; Tan, Jianglin; Zhou, Junyi; He, Weifeng; Li, Lanlan; Zhang, Jianxiang; Luo, Gaoxing; Qian, Wei

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2003-; Springer Science and Business Media LLC (ISSN 1477-3155)

Published

2020

Language

EN

Field

Engineering (Physical Sciences)