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Enhancement of Local Control in Locally Advanced Node-positive Nasopharyngeal Carcinoma by Adjunctive Chemotherapy by Peter Man Lung Teo; Anthony Tak Cheung Chan; Wai Yee Lee; Thomas Wai Tong Leung; Philip James Johnson is a Medicine article available to read on EtoBox.

What is Enhancement of Local Control in Locally Advanced Node-positive Nasopharyngeal Carcinoma by Adjunctive Chemotherapy about?

Purpose: To determine the efficacy of chemotherapy adjunctive to radical radiotherapy (neoadjuvant ؎ adjuvant) in patients with node-positive nasopharyngeal carcinoma (NPC). Methods and Materials: All the node-positive patients given adjunctive chemotherapy between 1984 -1989 (n ‫؍‬ 209, CHEMO) were compared with all the node-positive patients treated by radical radiotherapy alone during the same period (n ‫؍‬ 409, NCHEMO). The CHEMO group had significantly more bulky nodes, lower cervical/supraclavicular nodes, and more advanced overall stages than the NCHEMO group because nodal size (>4 cm) was used as a selection criterion for chemotherapy (1984 -1988 departmental protocol and 1988 -1989 prospective randomized trial). The chemotherapy consisted of two courses of neoadjuvant cisplatin (100 mg/m 2 D1) and 5-fluorouracil (5-FU) (1 gm/m 2 D1-D3) in 191 patients. In addition to the two courses of neoadjuvant, four courses of adjuvant chemotherapy, of the same combination, were given after radical radiotherapy in a further 18 patients. Radical radiotherapy delivered a nasopharyngeal dose of 60 -62.5 Gy. In addition, parapharyngeal booster external radiotherapy (20 Gy) was given in the

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Author

Peter Man Lung Teo; Anthony Tak Cheung Chan; Wai Yee Lee; Thomas Wai Tong Leung; Philip James Johnson

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

1999

Language

EN

Field

Medicine (Health Sciences)