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Onychomadesis and Phalanx Osteolysis in Congenital Insensitivity to Pain with Anhidrosis by Shu-Zhong Liu; Xi Zhou; An Song; Yi-Peng Wang; Yong Liu is a Medicine article available to read on EtoBox.

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## Onychomadesis and phalanx osteolysis in congenital insensitivity to pain with anhidrosis A 7-year-old girl presented to the orthopaedic clinic with nails peeling off and swelling of the left knee. The manifestation of onychomadesis had developed 1 year before her presentation. On physical examination, the digits of both hands were amputated distally (Fig. 1A). Her palms were warm and dry. On further questioning, her parents stated that the fingers of the patient had fallen off with no certain causes, and had been infected with pus several times. A thermal sweating test revealed complete anhidrosis and a palmar sympathetic skin response was not seen. Laboratory tests did not reveal any abnormity and no positive bone metabolism indexes were detected. Gene detection revealed pathogenic mutation in the NTRK1 gene. X-ray of the hands demonstrated significant bone destruction of distal phalanx, which revealed the appearance of phalanx osteolysis (Fig. 1B). Based on the criteria, onychomadesis and phalanx osteolysis in congenital insensitivity to pain with anhidrosis was diagnosed. This patient was treated with iodophors and NSAIDS. At the follow-up visit, her parents reported no progr

Who reads Onychomadesis and Phalanx Osteolysis in Congenital Insensitivity to Pain with Anhidrosis?

Author

Shu-Zhong Liu; Xi Zhou; An Song; Yi-Peng Wang; Yong Liu

Publisher

Oxford University Press; Oxford University Press (OUP) (ISSN 1462-0324)

Published

2020

Language

EN

Field

Medicine (Health Sciences)