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Long-term LVEF trajectories in patients with type 2 diabetes and heart failure: diabetic cardiomyopathy may underlie functional decline by Julián, María Teresa; Alonso, NÃoria; Lupón, Josep; Gavidia-Bovadilla, Giovana; Ferrer, Elena; de Antonio, Marta; López-Ayerbe, Jorge; Domingo, Mar; Santiago-Vacas, Evelyn; Zamora, Elisabet; Codina, Pau; Moliner, Pedro; NÃoñez, Julio; Santesmases, Javier; Puig-Domingo, Manel; Bayes-Genis, Antoni is a Medicine article available to read on EtoBox.

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## Background Left ventricular ejection fraction (LVEF) trajectories and functional recovery with current heart failure (HF) management is increasingly recognized. Type 2 diabetes mellitus (T2D) leads to a worse prognosis in HF patients. However, it is unknown whether T2D interferes with LVEF trajectories. The aim of this study was to prospectively assess very long-term (up to 15 years) LVEF trajectories in patients with and without T2D and underlying HF. ## Methods Ambulatory patients admitted to a multidisciplinary HF clinic were prospectively evaluated by scheduled two-dimensional echocardiography at baseline, 1 year, and then every 2 years afterwards, up to 15 years. Statistical analyses of LVEF change with time were performed using the linear mixed effects (LME) models, and locally weighted error sum of squares (Loess) curves were plotted. ## Results Of the 1921 patients, 461 diabetic and 699 non-diabetic patients with LVEF < 50% were included in the study. The mean number of echocardiography measurements performed in diabetic patients was 3.3 ± 1.6. Early LVEF recovery was similar in diabetic and non-diabetic patients, but Loess curves showed a more pronounced inverted U shap

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Author

Julián, María Teresa; Alonso, NÃoria; Lupón, Josep; Gavidia-Bovadilla, Giovana; Ferrer, Elena; de Antonio, Marta; López-Ayerbe, Jorge; Domingo, Mar; Santiago-Vacas, Evelyn; Zamora, Elisabet; Codina, Pau; Moliner, Pedro; NÃoñez, Julio; Santesmases, Javier; Puig-Domingo, Manel; Bayes-Genis, Antoni

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2002-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1475-2840)

Published

2020

Language

EN

Field

Medicine (Health Sciences)