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Can I read Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors on EtoBox?
Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors by Wenge Zhong; Hu Liu; Matthew R. Kaller; Charles Henley; Ella Magal; Thomas Nguyen; Timothy D. Osslund; David Powers; Robert M. Rzasa; Hui-Ling Wang; Weiya Wang; Xiaoling Xiong; Jiandong Zhang; Mark H. Norman is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors about?
Cyclin-dependent kinase 5 (CDK5) is a serine/threonine protein kinase and its deregulation is implicated in a number of neurodegenerative disorders such as Alzheimer's disease, amyotrophic lateral sclerosis, and ischemic stroke. Using active site homology modeling between CDK5 and CDK2, we explored several different chemical series of potent CDK5 inhibitors. In this report, we describe the design, synthesis, and CDK5 inhibitory activities of quinolin-2(1H)-one derivatives.
Who reads Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Wenge Zhong; Hu Liu; Matthew R. Kaller; Charles Henley; Ella Magal; Thomas Nguyen; Timothy D. Osslund; David Powers; Robert M. Rzasa; Hui-Ling Wang; Weiya Wang; Xiaoling Xiong; Jiandong Zhang; Mark H. Norman
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)