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Can I read Immune Signature of Multiple Sclerosis-associated Depression on EtoBox?
Immune Signature of Multiple Sclerosis-associated Depression by Jelena Brasanac; Caren Ramien; Stefanie Gamradt; Aline Taenzer; Laura Glau; Kristin Ritter; Kostas Patas; Agorastos Agorastos; Klaus Wiedemann; Cüneyt Demiralay; Felix Fischer; Christian Otte; Judith Bellmann-Strobl; Manuel A. Friese; Eva Tolosa; Friedemann Paul; Christoph Heesen; Martin Weygandt; Stefan M. Gold is a Neuroscience article available to read on EtoBox.
What is Immune Signature of Multiple Sclerosis-associated Depression about?
Multiple neurobiological pathways have been implicated in the pathobiology of major depressive disorder (MDD). The identification of reliable biological substrates across the entire MDD spectrum, however, is hampered by a vast heterogeneity in the clinical presentation, presumably as a consequence of heterogeneous pathobiology. One way to overcome this limitation could be to explore disease subtypes based on biological similarity such as “inflammatory depression”. As such a subtype may be particularly enriched in depressed patients with an underlying inflammatory condition, multiple sclerosis (MS) could provide an informative disease context for this approach. Few studies have explored immune markers of MS-associated depression and replications are missing. To address this, we analyzed data from two independent case-control studies on immune signatures of MS-associated depression, conducted at two different academic MS centers (overall sample size of n = 132). Using a stepwise data-driven approach, we identified CD4+CCR7lowTCM cell frequencies as a robust correlate of depression in MS. This signature was associated with core symptoms of depression and depression severity (but not M
Who reads Immune Signature of Multiple Sclerosis-associated Depression?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Jelena Brasanac; Caren Ramien; Stefanie Gamradt; Aline Taenzer; Laura Glau; Kristin Ritter; Kostas Patas; Agorastos Agorastos; Klaus Wiedemann; Cüneyt Demiralay; Felix Fischer; Christian Otte; Judith Bellmann-Strobl; Manuel A. Friese; Eva Tolosa; Friedemann Paul; Christoph Heesen; Martin Weygandt; Stefan M. Gold
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Neuroscience (Life Sciences)