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The review discusses in vivo chimeric antigen receptor (CAR) engineering as a promising approach for cancer immunotherapy, highlighting its advantages over traditional ex vivo methods, including streamlined production and reduced costs. Various strategies for in vivo CAR-T cell generation, such as lipid nanoparticles and viral delivery systems, are explored, showcasing their efficacy and safety in preclinical studies. The article also compares in vivo and ex vivo CAR engineering methods and addresses future

Author

manein

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EN