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Insights on genetic characterization and pathogenesis of a GI-19 (QX-like) infectious bronchitis virus isolated in China by Wenjun Yan; Qingcheng Yang; Siyu Huang; Song Liu; Kailu Wang; Yizhi Tang; Cangwei Lei; Hongning Wang; Xin Yang is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Insights on genetic characterization and pathogenesis of a GI-19 (QX-like) infectious bronchitis virus isolated in China about?
Infectious bronchitis virus (**IBV**) causes respiratory diseases in chickens, incurring great losses to the poultry industry worldwide. In this study, we isolated an IBV strain, designated as AH-2020, from the chickens vaccinated with H120 and 4/91 in Anhui, China. The sequence homology analysis based on the __S1__ gene revealed that AH-2020 shares low similarities with the 3 vaccine strains, namely, H120, LDT3-A, and 4/91 (78.19, 80.84, and 81.6%, respectively). Phylogenetic analysis based on the __S1__ gene revealed that AH-2020 clustered with the GI-19 type. Furthermore, protein modeling revealed that the mutations in the amino acids in AH-2020 were mainly located in the N-terminal domain of S1 (**S1-NTD**), and the pattern of deletion and insertion mutations in the S1 protein may have influenced the structural changes on the surface of S1. Further, approximately 7-day-old SPF chickens were inoculated with AH-2020 at 10^6.0^ EID~50~. These chickens exhibited clinical signs of the infection such as listlessness, huddling, and head-shaking, accompanied by depression and 40% mortality. Serum antibody test demonstrated that in response to the AH-2020 infection, the antibody level i
Who reads Insights on genetic characterization and pathogenesis of a GI-19 (QX-like) infectious bronchitis virus isolated in China?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Wenjun Yan; Qingcheng Yang; Siyu Huang; Song Liu; Kailu Wang; Yizhi Tang; Cangwei Lei; Hongning Wang; Xin Yang
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)